Кафедра неорганічної хімії (НХ)

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ENG: Department of Inorganic Chemistry

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    Gold Nanoparticles Stabilized With Aminopolycarboxylic Acids
    (Ukrainian State University of Science and Technologies, Dnipro, 2025) Тrunova, O. K.; Berezhnytska, O. S.; Rohovtsov, O. O.; Berzenina, Oksana V.; Khrokalo, L. A.; Semenets, Yu.V.
    ENG: This study presents the synthesis, morphological characterization, and preliminary antimicrobial evaluation of novel colloidal gold nanoparticle (AuNP) systems stabilized with aminopolycarboxylic acids: ethylenediaminetetraacetic acid (EDTA) and ethylenediaminedisuccinic acid (EDDS). These complexing agents act not only as chelators but also as simultaneous reducing and stabilizing agents in the formation of AuNPs, offering a green and environmentally friendly approach to nanomaterial fabrication. The synthesis was carried out under mild aqueous conditions without external protective additives, enabling the production of stable colloidal systems with minimal side products. The resulting nanoparticles were characterized by UV-Vis spectroscopy, FTIR spectroscopy, and scanning electron microscopy (SEM). Characteristic surface plasmon resonance (SPR) bands were observed in the 530–550 nm range, with their intensity and spectral position sensitive to pH, ligand nature, and stabilization time. The most stable and monodisperse systems were obtained at pH≈9, with spherical nanoparticles ranging in size from 8 to 20 nm. Particular emphasis was placed on evaluating the biological activity of the synthesized dispersions. Antimicrobial screening was performed against Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial strains. The results demonstrated moderate to high bactericidal activity, especially in EDTA-stabilized samples, likely due to enhanced surface stabilization and potential ligand involvement in membrane interactions.